To avoid the extensive first-pass effect, intranasal administration is chose after reconstitution.
加水重建后，选择鼻粘膜给药途径以避免药物的首过效应。
参考来源 - 鼻粘膜给药尼莫地平冷冻干燥脂质体的研究ODT has some advantages like quick absorption, high bioavailability, taking convenience, less residual in intestine. Furthermore, it can also avoid the first-pass effect of liver.
与普通制剂相比,口腔崩解片具有吸收快、生物利用度高、服用方便、肠道残留量少、部分避免肝脏首过作用、患者的顺应性好等优点。
参考来源 - 氟比洛芬口腔崩解片的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
以上来源于: WordNet
Objective: To explore the first-pass effect in Small intestine.
目的：探讨小肠在首过效应中的作用。
ConclusionThe metabolism of DBDCT in rat liver microsomes was faster, suggesting that the liver first-pass effect of the drug may be stronger.
结论DBDCT在大鼠肝微粒体中代谢较快，提示该药可能肝首过效应较强。
The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of nimodipine (NMD).
本文旨在寻找制备一个吸收良好、稳定性好、可避免尼莫地平强的首过效应的制剂。
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